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CRM1 Is a Cellular Target of Curcumin: New Insights for the Myriad of Biological Effects of an Ancient Spice
Author(s) -
Niu Mingshan,
Wu Sijin,
Mao Lei,
Yang Yongliang
Publication year - 2013
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12090
Subject(s) - curcumin , nuclear export signal , biology , biochemistry , mutant , cytoplasm , microbiology and biotechnology , computational biology , cell nucleus , gene
Curcumin, the major chemical constituent of turmeric plant, has entered clinical trial studies for its broad therapeutic properties. We present herein that CRM1 , an important nuclear shuttle protein, is a cellular target of curcumin by serious experimental and theoretical investigation. The inhibition of nuclear export by curcumin may account for its myriad biological effects, particularly for its therapeutic properties in cancer and inflammatory diseases. Our findings may have important implications for further clinical investigation of curcumin.