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Arv1 Regulates PM and ER Membrane Structure and Homeostasis But is Dispensable for Intracellular Sterol Transport
Author(s) -
Georgiev Alexander G.,
Johansen Jesper,
Ramanathan Vidhya D.,
Sere Yves Y.,
Beh Christopher T.,
Me Anant K.
Publication year - 2013
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12082
Subject(s) - biology , microbiology and biotechnology , intracellular , homeostasis , transport protein
Synopsis The ER membrane protein Arv1 has been implicated in intracellular sterol transport. We report that the retrograde and anterograde movement of sterols between the ER and PM in Saccharomyces cerevisiae is unaffected by Arv1 deficiency. Instead, we find that arv1 cells display altered ER morphology and PM lipid bilayer organization, and express tail‐anchored proteins at almost undetectable levels. Our results suggest that Arv1 plays a role in membrane homeostasis through its effect on the biogenesis of tail‐end membrane proteins.