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The ERM Proteins Ezrin and Moesin Regulate Retrograde Shiga Toxin Transport
Author(s) -
Kvalvaag Audun Sverre,
Pust Sascha,
Sundet Kristine Ingrid,
Engedal Nikolai,
Simm Roger,
Sandvig Kirsten
Publication year - 2013
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12077
Subject(s) - moesin , radixin , microbiology and biotechnology , ezrin , endosome , transport protein , biology , endocytosis , cytoskeleton , retromer , biochemistry , receptor , intracellular , cell
Synopsis Ezrin and moesin depletion leads to reduced binding of Shiga toxin (Stx), reduced retrograde Stx transport to the Golgi and protection from Stx toxicity. Endocytosed toxin seems to be arrested in hybrid compartments between early and late endosomal stages unable to recruit the retromer complex. Vps11 depletion on the other hand, leads to increased retrograde Stx transport. Finally, ezrin and moesin knockdown does not affect retrograde transport of ricin.