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Profiling thimet oligopeptidase‐mediated proteolysis in Arabidopsis thaliana
Author(s) -
Iannetta Anthony A.,
Rogers Holden T.,
AlMohanna Thualfeqar,
O’Brien Julia.,
Wommack Andrew J.,
Popescu Sorina C.,
Hicks Leslie M.
Publication year - 2021
Publication title -
the plant journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.058
H-Index - 269
eISSN - 1365-313X
pISSN - 0960-7412
DOI - 10.1111/tpj.15165
Subject(s) - proteostasis , arabidopsis , biology , arabidopsis thaliana , proteolysis , biochemistry , microbiology and biotechnology , proteomics , proteome , mutant , enzyme , gene
Significance Statement Arabidopsis thimet oligopeptidases (TOPs) are critical components in responses to stress, but their exact roles are not well characterized. Herein, a combination of quantitative in vivo peptidomics and in vitro validation was used to identify TOP substrates, providing a framework for TOP signaling networks and guiding future experiments in how the interplay between proteolytic pathways and defense signaling can be harnessed for the benefit of adaptation and tolerance mechanisms of crops.