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The Polycomb protein LHP 1 regulates Arabidopsis thaliana stress responses through the repression of the MYC 2‐dependent branch of immunity
Author(s) -
RamirezPrado Juan Sebastian,
Latrasse David,
RodriguezGranados Natalia Yaneth,
Huang Ying,
ManzaMianza Deborah,
BrikChaouche Rim,
Jaouannet Maelle,
Citerne Sylvie,
Bendahmane Abdelhafid,
Hirt Heribert,
Raynaud Cecile,
Benhamed Moussa
Publication year - 2019
Publication title -
the plant journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.058
H-Index - 269
eISSN - 1365-313X
pISSN - 0960-7412
DOI - 10.1111/tpj.14502
Subject(s) - biology , abscisic acid , psychological repression , microbiology and biotechnology , jasmonic acid , arabidopsis thaliana , pseudomonas syringae , arabidopsis , transcription factor , mutant , repressor , gene , genetics , gene expression
Summary Polycomb repressive complexes ( PRC s) have been traditionally associated with the regulation of developmental processes in various organisms, including higher plants. However, similar to other epigenetic regulators, there is accumulating evidence for their role in the regulation of stress and immune‐related pathways. In the current study we show that the PRC 1 protein LHP 1 is required for the repression of the MYC 2 branch of jasmonic acid ( JA )/ethylene ( ET ) pathway of immunity. Loss of LHP 1 induces the reduction in H3K27me3 levels in the gene bodies of ANAC 019 and ANAC 055, as well as some of their targets, leading to their transcriptional upregulation. Consistently, increased expression of these two transcription factors leads to the misregulation of several of their genomic targets. The lhp1 mutant mimics the MYC 2 , ANAC 019 , and ANAC 055 overexpressers in several of their phenotypes, including increased aphid resistance, abscisic acid (ABA) sensitivity and drought tolerance. In addition, like the MYC 2 and ANAC overexpressers, lhp1 displays reduced salicylic acid ( SA ) content caused by a deregulation of ICS 1 and BSMT 1 , as well as increased susceptibility to the hemibiotrophic pathogen Pseudomonas syringae pv. tomato DC 3000. Together, our results indicate that LHP 1 regulates the expression of stress‐responsive genes as well as the homeostasis and responses to the stress hormones SA and ABA . This protein emerges as a key chromatin player fine tuning the complex balance between developmental and stress‐responsive processes.