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Maintaining the factory: the roles of the unfolded protein response in cellular homeostasis in plants
Author(s) -
Angelos Evan,
Ruberti Cristina,
Kim SangJin,
Brandizzi Federica
Publication year - 2017
Publication title -
the plant journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.058
H-Index - 269
eISSN - 1365-313X
pISSN - 0960-7412
DOI - 10.1111/tpj.13449
Subject(s) - unfolded protein response , endoplasmic reticulum , protein folding , organism , microbiology and biotechnology , adaptation (eye) , cellular adaptation , effector , folding (dsp implementation) , biology , computational biology , neuroscience , genetics , engineering , gene , electrical engineering
Summary Much like a factory, the endoplasmic reticulum (ER) assembles simple cellular building blocks into complex molecular machines known as proteins. In order to protect the delicate protein folding process and ensure the proper cellular delivery of protein products under environmental stresses, eukaryotes have evolved a set of signaling mechanisms known as the unfolded protein response ( UPR ) to increase the folding capacity of the ER. This process is particularly important in plants, because their sessile nature commands adaptation for survival rather than escape from stress. As such, plants make special use of the UPR , and evidence indicates that the master regulators and downstream effectors of the UPR have distinct roles in mediating cellular processes that affect organism growth and development as well as stress responses. In this review we outline recent developments in this field that support a strong relevance of the UPR to many areas of plant life.