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PRC 1 is taking the lead in P c G repression
Author(s) -
Merini Wiam,
Calonje Myriam
Publication year - 2015
Publication title -
the plant journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.058
H-Index - 269
eISSN - 1365-313X
pISSN - 0960-7412
DOI - 10.1111/tpj.12818
Subject(s) - psychological repression , prc2 , epigenetics , mechanism (biology) , microbiology and biotechnology , gene , biology , genetics , histone h3 , gene expression , physics , quantum mechanics
Summary Polycomb group (PcG) proteins constitute a major epigenetic mechanism for gene repression throughout the plant life. For a long time, the PcG mechanism has been proposed to follow a hierarchical recruitment of PcG repressive complexes ( PRC s) to target genes in which the binding of PRC 2 and the incorporation of H3 lysine 27 trimethyl marks led to recruitment of PRC 1, which in turn mediated H2A monoubiquitination. However, recent studies have turned this model upside‐down by showing that PRC 1 activity can be required for PRC 2 recruitment and H3K27me3 marking. Here, we review the current knowledge on plant PRC 1 composition and mechanisms of repression, as well as its role during plant development.