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Haemoglobinopathy: considerations for reproductive health
Author(s) -
Supramaniam Prasanna Raj,
Mittal Monica,
Hay Deborah,
Narvekar Nitish,
Lim Lee Nai,
Becker Christian M
Publication year - 2018
Publication title -
the obstetrician and gynaecologist
Language(s) - English
Resource type - Journals
eISSN - 1744-4667
pISSN - 1467-2561
DOI - 10.1111/tog.12513
Subject(s) - medicine , reproductive health , gynecology , intensive care medicine , pregnancy , physiology , biology , environmental health , population , genetics
Key content An overview is given of the different types of haemoglobinopathies and the effect of iron overload on the function of vital organs, including the endocrine system. Assessment modalities for ovarian and testicular function measurement. Current management options for patients with hypogonadotrophic hypogonadism secondary to iron overload include chelation therapy from an early age and human menopausal gonadotrophin to induce ovulation and spermatogenesis. Egg, sperm or embryo donation remain alternative options in cases refractory to stimulation protocols. Cryopreservation is an option to retain future fertility in some patients with a haemoglobinopathy, but is not standard care. We consider the psychological impact of a haemoglobinopathy and iron overload, and their effects on reproductive health, as well as good medical support by a multidisciplinary team.Learning objectives To understand the current evidence of the impact of iron overload secondary to a haemoglobinopathy on reproductive health. To evaluate best practice and alternative options in the management of patients with iron overload in a reproductive health setting.