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The NSEBA Demonstration Project: implementation of a point‐of‐care platform for early infant diagnosis of HIV in rural Zambia
Author(s) -
Sutcliffe Catherine G.,
Moyo Nkumbula,
Schue Jessica L.,
Mutanga Jane N.,
Hamahuwa Mutinta,
Munachoonga Passwell,
Maunga Sylvia,
Thuma Philip E.,
Moss William J.
Publication year - 2021
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1111/tmi.13627
Subject(s) - medicine , genexpert mtb/rif , point of care testing , point of care , data collection , human immunodeficiency virus (hiv) , sample size determination , sample (material) , developing country , family medicine , pediatrics , emergency medicine , nursing , statistics , tuberculosis , mycobacterium tuberculosis , chemistry , mathematics , pathology , chromatography , economics , immunology , economic growth
Objectives To describe the experience and resource requirements of implementing point‐of‐care testing for early infant diagnosis of HIV in rural Zambia. Methods A demonstration project was conducted using a hub‐and‐spoke model in 2018–2019 at five clinics in rural Zambia. Two testing hubs were established, and all HIV‐exposed infants were tested with the GeneXpert system. Data on costs, turnaround times and test results were collected. Results Seven hundred and eighty six tests were conducted. At the hubs, results were available a median of 2.4 (IQR: 2.1, 2.8) hours after sample collection and most mothers (84%) received same‐day results. At the spoke facilities, results were available a median of 9 days (IQR: 7, 12) after sample collection and provided to the mother a median of 16 days (IQR: 10, 28) after sample collection. Eleven children tested positive, and 9 (82%) started treatment a median of 13 days (IQR: 7, 21) after sample collection and on the day mothers received results. In contrast, results from matching samples sent for routine testing were available a median of 38 days (IQR: 27, 61) after sample collection and provided to the mother a median of 91 days (IQR: 47, 135) after sample collection. Conclusions Implementing point‐of‐care testing in a network of rural health centres in Zambia required significant initial and ongoing investment in infrastructure, training and supervision. However, point‐of‐care testing can rapidly diagnose HIV‐infected infants, so they can benefit from early treatment.