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Drug‐related problems in prescribing for coronary artery diseases in Vietnam: cross‐sectional study
Author(s) -
Truong Thu T. A.,
Phan Ngan K.,
Vo Quyen V.,
Diep Han G.,
Vuong Huyen T. K.,
Le Thanh V.,
Nguyen Phuong M.,
Nguyen Thang
Publication year - 2019
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1111/tmi.13310
Subject(s) - medicine , confidence interval , odds ratio , cross sectional study , medical prescription , logistic regression , retrospective cohort study , pharmacoepidemiology , pediatrics , pathology , pharmacology
Objectives To determine the prevalence, patterns and determinants of drug‐related problems ( DRP s) in prescribing for coronary artery diseases ( CAD s) in Vietnam. Methods Retrospective cross‐sectional study on outpatients with CAD s at a general hospital in Can Tho, Vietnam. DRP s were classified according to Pharmaceutical Care Network Europe definitions. We determined the prevalence and patterns of DRP s. Logistic regression was used to identify the determinants of DRP s. Results Among 683 patients (mean age 63.4; 64.3% female), the prevalence of DRP s was 61.1%. DRP s comprised inappropriate indication (3.5%), inappropriate dosage (22.2%), wrong frequency of use (24.2%), wrong time of taking medications (4.1%), taking medications at the wrong time around meals (19.2%) and drug interactions (19.3%). Patients who took ≥ 5 drugs were more likely to have DRP s (adjusted odds ratio = 1.96; 95% confidence interval = 1.31–2.93). Patients without health insurance were more likely to have inappropriate indication ( OR a = 2.93; 95% CI = 1.28–6.70). Taking medications at inappropriate times around meals was common among men ( OR a = 1.82; 95% CI = 1.23–2.69) and among those with health insurance ( OR a = 1.66; 95% CI = 1.05–2.63). Patients < 65 years old were more likely to be prescribed inappropriate doses ( OR a = 1.67; 95% CI = 1.15–2.45). Prescriptions with ≥ 5 drugs were more likely to be taken at inappropriate frequency ( OR a = 1.87; 95% CI = 1.09–3.21) and to cause drug interactions ( OR a = 6.48; 95% CI = 2.59–16.24). Conclusions DRP s are common among patients with CAD s in Vietnam. The number of DRP s increases with the number of drugs in prescriptions. Further studies should identify other potential determinants of DRP s and effective interventions to improve prescribing practice in Vietnam.