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Association of HIV status with infection by multiple HPV types
Author(s) -
Camargo Milena,
Del RíoOspina Luisa,
SotoDe León Sara Cecilia,
Sánchez Ricardo,
PinedaPeña Andrea Clemencia,
Sussmann Otto,
Patarroyo Manuel Elkin,
Patarroyo Manuel Alfonso
Publication year - 2018
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1111/tmi.13142
Subject(s) - medicine , hpv infection , cervix , odds ratio , population , cervical cancer , logistic regression , viral load , obstetrics , gynecology , immunology , human immunodeficiency virus (hiv) , cancer , environmental health
Objectives To identify the clinical and demographic characteristics of HIV ‐positive and HIV ‐negative women infected by multiple HPV types. Methods 1399 women participated in the study (240 HIV ‐positive and 1159 HIV ‐negative women). Samples were provided for Pap tests and for HPV detection and typing by PCR . Data were collected on HPV infection, frequency of multiple infection, and HPV type distribution. Odds ratios were reported from logistic regression models. Results Compared with HIV ‐negative women, HIV ‐positive women had higher frequencies of cervical abnormality (30% vs . 20.8%), higher HPV prevalence (68.3% vs . 51.3%) and were more commonly infected with multiple HPV types (78.7% vs . 44.3%). HPV ‐16 was the most common type detected in the study population, with other types showing variable associations with HIV status. Positive associations were observed between infection by multiple HPV types and HIV status, cervical abnormality and having had more than three pregnancies. The odds of multiple infection by HPV types were higher in HIV ‐positive women who used an intrauterine device, who had a history of abortions and who had HIV viral loads >100 000 copies/ml, whilst the odds were lower in women with >500 CD 4 cells/mm 3 . Conclusions HIV immunosuppression favours infection by multiple high‐risk HPV types, mainly in women affected by low‐grade squamous intraepithelial lesions. Antiretroviral therapy had no effect on infection by multiple HPV types. Risk factors related to progressive damage to the cervix were positively associated with infection by multiple HPV types in women living with HIV .