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Correlation of ABH blood group antigens secretion with H elicobacter pylori infection in Pakistani patients
Author(s) -
Ansari Shazia Akbar,
Khan Adnan,
Khan Taseer Ahmed,
Raza Yasir,
Syed Sofia Ali,
Akhtar Syed Shakeel,
Kazmi Shahana Urooj
Publication year - 2015
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1111/tmi.12401
Subject(s) - saliva , abo blood group system , antigen , medicine , gastroenterology , immunology , helicobacter pylori , rapid urease test , gastritis
Objectives A and B blood group antigens are fucosylated carbohydrate present on human erythrocytes and body secretions. Their presence in body secretions depends on the expression of a dominant allele of secretor gene FUT 2 and is correlated with susceptibility to various infectious and non‐infectious diseases. We investigated the correlation of blood group and ABH antigen secretion with H elicobacter pylori infection and gastroduodenal symptoms and analysed the distribution of bab A gene among ABH secretors and non‐secretors. Methods Two hundred and ninety patients who underwent gastroduodenal endoscopy during 2011 to 2012 participated. Gastric biopsy, saliva and blood samples were obtained from every patient. Gastric biopsies were subjected to rapid urease test and PCR for the detection of H . pylori and bab A gene. Blood grouping and ABH antigens secretions were determined by Lewis blood group phenotyping and haemagglutination inhibition test. Results 50.34% of patients were ABH antigen secretors and 45.51% non‐secretors. Distribution analysis of blood group revealed that 40 blood group B, 67 blood group A 20 blood group O and 19 blood group AB patients secreted ABH antigens in saliva. Fifty‐six blood group O, 19 blood group B, 32 blood group A and 17 blood group AB patients were non‐secretors. Gastroduodenal complaints were common among non‐secretors. Sixty‐two percent of patients with a combination of duodenal ulcer and gastro‐oesophageal reflux and 54% of patients with gastritis were non‐secretors. Of 290 samples, 31.02% were positive for H . pylori . Thirty percent of these tested positive for bab A gene; the majority belonged to non‐secretor blood group O. Conclusions Our results suggest that the infection of H . pylori is correlated with ABO blood groups and blood group antigens secretion in body fluids.