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Random blood glucose may be used to assess long‐term glycaemic control among patients with type 2 diabetes mellitus in a rural African clinical setting
Author(s) -
Rasmussen Jon B.,
Nordin Lovisa S.,
Rasmussen Niclas S.,
Thomsen Jakúp A.,
Street Laura A.,
Bygbjerg Ib C.,
Christensen Dirk L.
Publication year - 2014
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1111/tmi.12391
Subject(s) - medicine , creatinine , body mass index , diabetes mellitus , gastroenterology , type 2 diabetes , type 2 diabetes mellitus , waist , rank correlation , endocrinology , machine learning , computer science
Objectives To investigate the diagnostic accuracy of random blood glucose ( RBG ) on good glycaemic control among patients with diabetes mellitus ( DM ) in a rural African setting. Methods Cross‐sectional study at St. Francis' Hospital in eastern Zambia. RBG and HbA 1c were measured during one clinical review only. Other information obtained was age, sex, body mass index, waist circumference, blood pressure, urine albumin–creatinine ratio, duration since diagnosis and medication. Results One hundred and one patients with DM (type 1 DM = 23, type 2 DM = 78) were included. Spearman's rank correlation coefficient revealed a significant correlation between RBG and HbA 1c among the patients with type 2 DM ( r = 0.73, P < 0.001) but not patients with type 1 DM ( r = 0.17, P = 0.44). Furthermore, in a multivariate linear regression model ( R 2 = 0.71) RBG (per mmol/l increment) ( B = 0.28, 95% CI :0.24–0.32, P < 0.001) was significantly associated with HbA 1c among the patients with type 2 DM . Based on ROC analysis ( AUC = 0.80, SE = 0.05), RBG ≤7.5 mmol/l was determined as the optimal cut‐off value for good glycaemic control (HbA 1c <7.0% [53 mmol/mol]) among patients with type 2 DM (sensitivity = 76.7%; specificity = 70.8%; positive predictive value = 62.2%; negative predictive value = 82.9%). Conclusions Random blood glucose could possibly be used to assess glycaemic control among patients with type 2 DM in rural settings of sub‐Saharan Africa.