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High‐performance thin layer chromatography to assess pharmaceutical product quality
Author(s) -
Kaale Eliangiringa,
Manyanga Vicky,
Makori Narsis,
Jenkins David,
Michael Hope Samuel,
Layloff Thomas
Publication year - 2014
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1111/tmi.12303
Subject(s) - active ingredient , thin layer chromatography , chromatography , ingredient , high performance thin layer chromatography , thin layer , quality assessment , quality (philosophy) , relative standard deviation , chemistry , mathematics , medicine , food science , layer (electronics) , reliability engineering , evaluation methods , engineering , pharmacology , physics , organic chemistry , quantum mechanics , detection limit
Objective To assess the sustainability, robustness and economic advantages of high‐performance thin layer chromatography ( HPTLC ) for quality control of pharmaceutical products. Method We compared three laboratories where three lots of cotrimoxazole tablets were assessed using different techniques for quantifying the active ingredient. Result The average assay relative standard deviation for the three lots was 1.2 with a range of 0.65–2.0. Conclusion H igh‐performance thin layer chromatography assessments are yielding valid results suitable for assessing product quality. The local pharmaceutical manufacturer had evolved the capacity to produce very high quality products.