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Haematological and biochemical reference values of G ambian infants
Author(s) -
Odutola Aderonke A.,
Afolabi Muhammed O.,
Jafali James,
Baldeh Ignatius,
Owolabi Olumuyiwa A.,
Owiafe Patrick,
Bah Gibril,
Jaiteh Boto,
Mohammed Nuredin I.,
Donkor Simon A.,
Ndure Jorjoh,
Adetifa Jane,
Flanagan Katie L.,
Ota Martin O. C.
Publication year - 2014
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1111/tmi.12245
Subject(s) - reference values , creatinine , medicine , alkaline phosphatase , white blood cell , reference range , physiology , zoology , immunology , biology , biochemistry , enzyme
Objective To establish haematological and biological reference values for G ambian infants. Methods Basic haematological and biochemical indices were analysed in blood samples obtained from healthy infants from S ukuta in the W estern D ivision of T he G ambia. The 2.5 and the 97.5 centiles for these indices were estimated. Results Reference ranges for haematological and biochemical indices were determined. Haemoglobin, total white cell count ( WBC ) and platelet levels decreased with age ( P < 0.001), whereas most of the white cell count subsets except monocytes did not vary with age. Potassium and alkaline phosphatase fell significantly with increasing age ( P < 0.001; P < 0.001), whereas urea and creatinine rose with increasing age ( P = 0.002; P < 0.001, respectively). Conclusion Our set of haematological and biochemical reference values for healthy infants in T he G ambia differs from values in other settings, thus underscoring the importance of establishing region‐specific paediatric reference ranges to ensure optimal patient management and evaluate the impact of interventions in clinical research.