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Distribución del virus del papiloma humano en el carcinoma cervical invasivo en África subsahariana: ¿Puede el VIH explicar las diferencias?
Author(s) -
Ndiaye Cathy,
Alemany Laia,
Ndiaye Nafissatou,
Kamaté Bakarou,
Diop Yankhoba,
Odida Michael,
Banjo Kunbi,
Tous Sara,
Klaustermeier Jo Ellen,
Clavero Omar,
Castellsagué Xavier,
Xavier Bosch F.,
Trottier Helen,
de Sanjosé Silvia
Publication year - 2012
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1111/tmi.12004
Subject(s) - medicine , cervical cancer , gynecology , genotyping , human papillomavirus , cervical screening , oncology , virology , cancer , genotype , biology , genetics , gene
Objectives To describe human papillomavirus (HPV) distribution in invasive cervical carcinoma (ICC) from Mali and Senegal and to compare type‐specific relative contribution among sub‐Saharan African (SSA) countries. Methods A multicentric study was conducted to collect paraffin‐embedded blocks of ICC. Polymerase chain reaction, DNA enzyme immunoassay and line probe assay were performed for HPV detection and genotyping. Data from SSA (Mozambique, Nigeria and Uganda) and 35 other countries were compared. Results One hundred and sixty‐four ICC cases from Mali and Senegal were tested from which 138 were positive (adjusted prevalence = 86.8%; 95% CI = 79.7–91.7%). HPV16 and HPV18 accounted for 57.2% of infections and HPV45 for 16.7%. In SSA countries, HPV16 was less frequent than in the rest of the world (49.4% vs . 62.6%; P < 0.0001) but HPV18 and HPV45 were two times more frequent (19.3% vs . 9.4%; P < 0.0001 and 10.3% vs . 5.6%; P < 0.0001, respectively). There was an ecological correlation between HIV prevalence and the increase of HPV18 and the decrease of HPV45 in ICC in SSA ( P = 0.037 for both). Conclusion HPV16/18/45 accounted for two‐thirds of the HPV types found in invasive cervical cancer in Mali and Senegal. Our results suggest that HIV may play a role in the underlying HPV18 and HPV45 contribution to cervical cancer, but further studies are needed to confirm this correlation.