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Multicentre evaluation of Erytra Eflexis®, a benchtop fully automated analyser with a compact design for routine use in blood transfusion laboratory
Author(s) -
Elliott C.,
Carrascosa T.,
Souchet J.L.,
Smith D.,
Malaxetxebarria I.,
You J.,
Bendahan M.,
Barnes S.,
Lisle F.,
Whitehouse N.
Publication year - 2019
Publication title -
transfusion medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.471
H-Index - 59
eISSN - 1365-3148
pISSN - 0958-7578
DOI - 10.1111/tme.12619
Subject(s) - analyser , medicine , abo blood group system , false positive paradox , blood transfusion , computer science , surgery , chromatography , artificial intelligence , chemistry
Summary Objectives Evaluation of the compact benchtop Erytra Eflexis® automated analyser was performed at three health centres representing a range of routine transfusion workload. Background Automation instruments with the simplicity and flexibility adequate for small‐ to mid‐sized blood transfusion services are an unmet need. Methods Performance in pre‐transfusion testing (2109 ABO/D, 382 Rh/K phenotype, 2001 antibody screening, 113 antibody identification, 151 DAT, 88 extended phenotype; 655 cross matching) in comparison to Erytra® as reference device was assessed. Throughput [time to first result (TTFR), final turn‐around time (TAT), processing rate] was calculated; usability and adaptability in laboratory practice under routine and with emergency samples were surveyed. Results Agreement between systems was 99·8% (11/5499 test discrepancies, all due to weak/doubtful positive reactions). Erytra Eflexis produced six true positives (two Rh/D, two B positives, two screening), four false positives (three screening and one cross matching) and one false negative (screening). Processing of eight routine samples with the Erytra Eflexis for ABO/Rh(D) and screening took 34–38 min and 32–37 min, respectively, independent of the simultaneous processing of a STAT sample, whether or not the incubator for STAT was reserved. In this scenario, a STAT sample requested within 2 min after the routine load was processed in 14–26 min. Processing rate tended to stabilise and optimise in the larger workloads, particularly in ABO/Rh(D)/K cards (16·7, 18 and 19·5 results/h for 10, 15 and 24 specimens, respectively). Conclusion Erytra Eflexis analyser was found to be reliable and suitable for pre‐transfusion routine tests performed in a small‐/medium‐sized blood transfusion laboratory.