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Platelet transfusion thresholds in premature neonates (PlaNeT‐2 trial)
Author(s) -
Estcourt L. J.
Publication year - 2019
Publication title -
transfusion medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.471
H-Index - 59
eISSN - 1365-3148
pISSN - 0958-7578
DOI - 10.1111/tme.12587
Subject(s) - medicine , platelet , bleed , platelet transfusion , pediatrics , surgery
Summary Clinical question Does transfusing platelets to preterm infants (< 34 weeks) at a higher platelet count threshold count (< 50 x 10 9 /L) reduce the risk of major bleeding or death compared to only transfusing platelets when the platelet count drops below 25 x 10 9 /L. Evidence from trial Preterm infants with a low platelet count who were transfused platelets at the higher platelet count threshold had a higher risk of dying or having a major bleed than those who were not. The reasons why this occurred are currently unclear.