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Red blood cell storage duration and long‐term mortality in patients undergoing cardiac intervention: a Danish register study
Author(s) -
Dencker D.,
Pedersen F.,
Engstrøm T.,
Schroeder T. V.,
Lönn L.,
Johansson P. I.,
De Backer O.
Publication year - 2017
Publication title -
transfusion medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.471
H-Index - 59
eISSN - 1365-3148
pISSN - 0958-7578
DOI - 10.1111/tme.12435
Subject(s) - medicine , survival analysis , observational study , surgery
Objectives To study the effect of red blood cell ( RBC ) storage duration on long‐term mortality in patients undergoing cardiac intervention. Background RBCs undergo numerous structural and functional changes during storage. Observational studies have assessed the association between RBC storage duration and patient outcomes with conflicting results. Methods Between January 2006 and December 2014, 82 408 patients underwent coronary angiography. Of these, 1856 patients received one to four RBC units within 30 days after this procedure. Patients were allocated according to length of RBC storage duration: short‐term (≤11 days), intermediate ( IM )‐term (12–23 days) and long‐term (≥24 days). The study endpoints were 30‐day and long‐term all‐cause mortality. Results A total of 4168 RBC units were given to 1856 patients. The mean RBC storage duration was 8.5 ± 2.1, 17.7 ± 3.4 and 29.9 ± 3.4 days in the short‐term, IM ‐term and long‐term storage groups, respectively. There was no difference in baseline characteristics between the groups. The long‐term storage group received significantly more units (2.4 ± 1.0 units) as compared to the short‐term (2.0 ± 1.0 units; P < 0.001) and IM ‐term storage group (2.2 ± 1.0 units; P < 0.01). In the survival analysis, there was no significant difference in all‐cause mortality between the groups (log‐rank: 0.509 for 30‐days mortality; 0.493 for 5‐year mortality). Additional stratified analysis demonstrated no association between RBC storage duration and long‐term mortality. Conclusion This study did not find an association between RBC storage duration and 30‐days or long‐term mortality in patients undergoing cardiac intervention.