Improvement of plateletpheresis via technical modification on the MCS +

SUMMARY Background With the advantage of easy operation and high reliability, Haemonetics multicomponent collection system ( MCS +) is widely used as a blood cell separator in clinical application. Objectives The aim of this study was to evaluate the effect of technical parameter modification as utilised on the MCS + to improve the quality of platelet yielded as well as donor comfort. Methods After informed consent, a total of 118 donors, well matched for baseline parameters, were included in the study from December 2012 to April 2013. Sixty‐one donors underwent single‐dose plateletpheresis ( SDP ), and the other 57 donors underwent double‐dose plateletpheresis ( DDP ) before and after technical modification on the MCS +, respectively, according to the manufacturer's instructions. The procedures were evaluated, focusing on whole blood processed ( WBP ), processing time ( PT ) and number of cycles were measured, as well as the quality of products. Results No severe adverse reaction was found during donation. WBP , PT and number of cycles after modification were all reduced significantly in both SDP and DDP groups ( P  < 0·01). In addition, 80·51 % (95 in 118) of the total post‐modification products were qualified, presenting with high quality. Besides, the comfort of donors was also improved probably because of the reduced PT . Conclusion Adjustment of the relevant technical parameters on MCS + could produce a beneficial effect on the procedure measures and ensure a high‐quality platelet production.