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Transplantation programs facing lack of empirical evidence on SARS‐CoV‐2 vaccination: A society recommendation consensus update
Author(s) -
Nevermann Nora,
Wiering Leke,
Wu Helen,
Moroder Philipp,
Brandl Andreas,
Globke Brigitta,
Krenzien Felix,
Raschzok Nathanael,
Schöning Wenzel,
Lurje Georg,
Öllinger Robert,
Schmelzle Moritz,
Pratschke Johann,
Ritschl Paul Viktor
Publication year - 2021
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.13696
Subject(s) - medicine , covid-19 , vaccination , consensus conference , transplantation , real world evidence , intensive care medicine , medline , virology , family medicine , pathology , law , infectious disease (medical specialty) , outbreak , political science , disease
Background Since phase III trials for the most prominent vaccines excluded immunocompromised or immunosuppressed patients, data on safety and efficacy of SARS‐CoV‐2 vaccines for recipients of solid organ transplantations are scarce. Aims Our study offers a synthesis of expert opinions aligned with available data addressing key questions of the clinical management of SARS‐CoV‐2 vaccinations for transplant patients. Method An online research was performed retrieving available recommendations by national and international transplantation organizations and state institutions on SARS‐CoV2 vaccination management for transplant recipients. Results Eleven key statements were identified from recommendations by 18 national and international societies, and consensus for the individual statements was evaluated by means of the Society Recommendation Consensus score. The highest consensus level (SRC A) was found for prioritized access to vaccination for transplant patients despite anticipation of a weakened immune response. All currently authorized vaccines can be considered safe for transplant patients (SRC A). The handling of immunosuppressive medication, the timely management of vaccines, and other aspects were aligned with available expert opinions. Conclusion Expert consensus can be determined for crucial aspects of the implementation of SARS‐CoV‐2 vaccination programs. We hereby offer a tool for immediate decision‐making until empirical data becomes available.