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Donor‐derived human herpesvirus 8 infection with Kaposi sarcoma and Kaposi sarcoma inflammatory cytokine syndrome in a heart transplant recipient: A case report
Author(s) -
Antonio Russo,
Laura Giovannini,
Nicolina Conti,
Elena Sabattini,
Luca Vizioli,
Tiziana Lazzarotto,
Luciano Potena,
Davide Pacini,
Nazzareno Galie’
Publication year - 2021
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.13609
Subject(s) - medicine , cytopenia , sarcoma , malignancy , immunology , heart transplantation , kaposi's sarcoma , complication , transplantation , pathology , human herpesvirus , bone marrow
Human herpesvirus‐8 (HHV‐8) infection is associated with neoplastic and non‐neoplastic diseases in immunocompromised patients. Kaposi sarcoma (KS) is a common malignancy reported in solid organ transplant recipients (SOTR). Kaposi sarcoma inflammatory cytokine syndrome (KICS), initially described in HIV patients, is characterized by high viral loads, elevated levels of cytokines, cytopenia, high fever, organ failure, and poor outcome. We report the case of a 54‐year‐old patient who developed simultaneous occurrence of KS of lymph nodes and KICS as a complication of primary donor‐transmitted HHV‐8 infection, after heart transplantation (HT). The diagnosis, management, and prognosis of this condition are unclear and needs a multidisciplinary approach.