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Detection of adenovirus hepatitis and acute liver failure in allogeneic hematopoietic stem cell transplant patients
Author(s) -
Onda Yoshiyuki,
Kanda Junya,
Sakamoto Soichiro,
Okada Mutsumi,
Anzai Naoyuki,
Umadome Hiroshi,
Tashima Masaro,
Haga Hironori,
Watanabe Chihiro,
Hanaoka Nozomu,
Fujimoto Tsuguto,
TakaoriKondo Akifumi
Publication year - 2021
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.13496
Subject(s) - medicine , hematopoietic stem cell transplantation , hepatitis , pneumonia , immunology , hemorrhagic cystitis , encephalitis , disease , virology , virus
Human adenovirus (HAdV) is an important cause of the common cold and epidemic keratoconjunctivitis in immunocompetent individuals. In immunocompromised patients, HAdV can sometimes cause severe infection such as cystitis, gastroenteritis, pneumonia, encephalitis, hepatitis, or disseminated disease, resulting in significant morbidity and also mortality. In particular, severe cases have been reported in patients after allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Indeed HAdV has been recognized as a pathogen that requires careful monitoring in allo‐HSCT patients. While HAdV hepatitis leading to severe acute liver failure is rare, such liver failure progresses rapidly and is often fatal. Unfortunately, HAdV hepatitis has few characteristic symptoms and physical findings, which makes it difficult to promptly confirm and start treatment. We report here four cases of HAdV hepatitis after allo‐HSCT and their autopsy findings.