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Unilateral leg pain caused by cryptococcal myositis: An unusual presentation of disseminated cryptococcosis in a kidney transplant recipient
Author(s) -
Lier Audun J.,
Virmani Sarthak,
IlaganYing Ysabel,
Leelatian Nalin,
Darbinyan Armine,
Malinis Maricar F.
Publication year - 2021
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.13491
Subject(s) - medicine , cryptococcus neoformans , myositis , immunosuppression , cryptococcus , pneumonia , cryptococcosis , septic shock , fluconazole , opportunistic infection , surgery , sepsis , pathology , dermatology , immunology , antifungal , human immunodeficiency virus (hiv) , genetics , viral disease , microbiology and biotechnology , biology
Cryptococcal disease is a rare but often serious infection in solid organ transplant recipients, commonly presenting as meningitis and pneumonia but can rarely cause myositis. We report the case of a 43‐year‐old female kidney transplant recipient with two previous graft failures requiring re‐transplantations who presented with a 1‐month duration of worsening unilateral leg pain, swelling, and shortness of breath. Blood cultures isolated Cryptococcus neoformans . A calf biopsy was performed and histopathology revealed myonecrosis with yeast forms consistent with Cryptococcus spp. Liposomal amphotericin B (LamB) was administered. Her course was complicated by hypoxemic respiratory failure with development of ground glass opacities on chest imaging. Work‐up revealed bacterial and C neoformans pneumonia and probable Pneumocystis jirovecii pneumonia (PJP) She received trimethoprim‐sulfamethoxazole and LamB and was discharged on fluconazole. Shortly thereafter she was re‐admitted with confusion, septic shock, and multi‐organ failure. Work‐up revealed PJP with subsequent development of cryptococcal meningitis. Despite aggressive management, she expired. Disseminated cryptococcal infection may manifest as myositis. Presence of cryptococcal infection is a marker of severe net state of immunosuppression (IS), hence, presence of other opportunistic infections is likely. Early recognition of cryptococcal infection, institution of targeted therapy, and IS reduction are important to improve overall survival.