Premium
Successful cord blood transplantation for myelodysplastic syndrome complicated by Mycobacterium kansasii pneumonia
Author(s) -
Yamada Arisa,
Akahane Daigo,
Katagiri Seiichiro,
Yoshizawa Seiichiro,
Furuya Nahoko,
Fujimoto Hiroaki,
Gotoh Moritaka,
Gotoh Akihiko
Publication year - 2021
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.13463
Subject(s) - mycobacterium kansasii , medicine , pneumonia , hematopoietic stem cell transplantation , sputum , transplantation , immunology , mycobacterium , pathology , tuberculosis
Non‐tuberculous mycobacterial (NTM) disease is a rare cause of neutropenic fever in patients with hematological malignancies. There are few studies on the optimal management for such patients with NTM. We report a case of myelodysplastic syndrome (MDS) treated by umbilical cord blood transplantation (CBT) after Mycobacterium kansasii ( M kansasii ) pneumonia. A 38‐year‐old man diagnosed with MDS developed severe pneumonia during induction chemotherapy. Repeated sputum culture uncovered mycobacterium infection. Then, by the polymerase chain reaction of the bronchial lavage fluid, M kansasii infection was proven. After 140 days of anti‐NTM therapy, CBT was successfully carried out and the patient recovered without recurrence of NTM infection. This case provides valuable evidence that hematopoietic stem cell transplantation is feasible after a reliable diagnosis and continuous anti‐NTM therapy.