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Very late‐onset cytomegalovirus disease with ganciclovir resistance >15 years following renal transplantation
Author(s) -
Khan Sadid F.,
Yong Michelle K.,
Slavin Monica A.,
Hughes Peter,
Sasadeusz Joseph
Publication year - 2021
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.13441
Subject(s) - medicine , ganciclovir , transplantation , cytomegalovirus , disease , kidney transplantation , organ transplantation , betaherpesvirinae , immunology , intensive care medicine , human cytomegalovirus , viral disease , herpesviridae , virus
Cytomegalovirus (CMV) infection is a significant cause of morbidity and mortality after solid organ transplantation. There has been a significant shift in disease epidemiology with the introduction of antiviral prophylaxis, with CMV disease occurring later and clinical presentations more atypical. We describe two cases of very late‐onset CMV disease where first disease occurred 15 and 18 years post–renal transplantation, with both cases complicated by antiviral drug resistance. We subsequently review the published cases and literature of very late‐onset CMV disease (onset > 10 years post–solid organ transplantation) as an increasingly recognized phenomenon which is emerging as an important aspect in improving long‐term patient outcomes in the current era of renal transplantation.