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Clinical characteristics and outcome of COVID‐19 pneumonia in kidney transplant recipients in Razi hospital, Rasht, Iran
Author(s) -
Monfared Ali,
DashtiKhavidaki Simin,
Jafari Ramezan,
Jafari Atefeh,
Ramezanzade Elham,
Lebadi MohamadKazem,
HaghdarSaheli Yalda,
Aghajanzadeh Pegah,
Khosravi Masoud,
Movassaghi Ali,
TaghvayeMasoumi Hamidreza,
Alavi Foumani Ali
Publication year - 2020
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.13420
Subject(s) - medicine , interquartile range , pneumonia , immunosuppression , prednisolone , kidney transplantation , prednisone , observational study , kidney , acute kidney injury
Background In late December 2019, a novel coronavirus SARS‐CoV‐2 started to spread around the world in different populations. Its clinical and laboratory characteristics and outcome in kidney transplant recipients are little known. Therefore, we describe 22 kidney transplant recipients with SARS‐CoV‐2–induced pneumonia. Methods All kidney transplant recipients who referred to the Razi Hospital of Rasht with a diagnosis of SARS‐CoV‐2 infection from February 20 to 19th of April 2020 have been included in this observational study. Results We present 22 cases of COVID‐19 in kidney transplant recipients (median age 52 years [interquartile range 40.75‐62.75 years]) and baseline eGFR 60 (mL/min/1.73 m 2 ) (44.75‐86.75). Patients complained of cough (72.7%), dyspnea (63.6%), fever (68.2%), and chill (72.7%) with greater prevalence. We decreased the dose of immunosuppression and started stress dose of intravenous hydrocortisone or equivalent oral prednisolone. Each patient received antiviral therapy based on the latest updated version of local protocol at the time of admission. CT scan findings in 90.9% of patients showed bilateral multifocal lesions. Acute kidney injury (AKI) was observed in 12 patients during hospitalization. Six patients died after a median of 12 days from admission (IQR, 1‐21). Conclusions In this small observational study, we observed high AKI occurrence and mortality rate in kidney transplant recipients with COVID‐19.