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Trichodysplasia spinulosa: Case reports and review of literature
Author(s) -
Jose Aju,
Dad Taimur,
Strand Andrew,
Tse Julie Y.,
Plotnikova Natalia,
Boucher Helen W.,
Sarnak Mark J.,
Gilbert Scott J.,
Goyal Nitender
Publication year - 2020
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.13342
Subject(s) - medicine , cidofovir , immunosuppression , valganciclovir , dermatology , basiliximab , intensive care medicine , transplantation , surgery , immunology , kidney transplantation , ganciclovir , virus , human cytomegalovirus
Trichodysplasia spinulosa (TS) is a rare skin condition caused by trichodysplasia spinulosa‐associated polyomavirus (TSPyV). It affects immunosuppressed patients, and <50 cases have been reported. The majority of these cases are seen in solid organ transplant recipients. TS often poses a diagnostic and therapeutic challenge because of its rarity and resemblance with other skin conditions. Several forms of treatment are usually tried prior to establishing a definitive diagnosis. Oral valganciclovir and topical cidofovir have been found to give the best results and hence are the most commonly used agents once the diagnosis is established. Here, we present two cases with a review of literature of TS in solid organ transplant recipients, focusing on time to develop the condition post‐transplant, immunosuppression regimen used, and treatment initiated both before and after a definitive diagnosis.

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