Successful treatment of  Aspergillus fumigatus  sternal osteomyelitis with isavuconazole in a heart transplant recipient | Zendy

Assaf Ady | Zendy; Faure Emmanuel | Zendy; Sermet Kevin | Zendy; Loridant Severine | Zendy; Leroy Jordan | Zendy; Goeminne Celine | Zendy; Dozier Aurelie | Zendy; Chopin MarieCharlotte | Zendy; Panaget Sophie | Zendy; Faure Karine | Zendy; Vuotto Fanny | Zendy

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Successful treatment of Aspergillus fumigatus sternal osteomyelitis with isavuconazole in a heart transplant recipient

Author(s) -

Assaf Ady,

Faure Emmanuel,

Sermet Kevin,

Loridant Severine,

Leroy Jordan,

Goeminne Celine,

Dozier Aurelie,

Chopin MarieCharlotte,

Panaget Sophie,

Faure Karine,

Vuotto Fanny

Publication year - 2020

Publication title -

transplant infectious disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.69

H-Index - 67

eISSN - 1399-3062

pISSN - 1398-2273

DOI - 10.1111/tid.13313

Subject(s) - voriconazole , discontinuation , medicine , aspergillus fumigatus , osteomyelitis , aspergillosis , surgery , sternum , heart transplantation , caspofungin , transplantation , antifungal , dermatology , immunology

A 65‐year‐old man was diagnosed with an invasive Aspergillus fumigatus infection with sternal osteomyelitis 4 months after heart transplantation. Unfortunately, after 8 weeks patient developed severe cutaneous and neurological toxicities induced by voriconazole leading to drug discontinuation. Therefore, isavuconazole was chosen as second‐line therapy. The patient presented a favorable outcome and tolerance was excellent after ten months monotherapy. Here, we report for a first time, an successful isavuconazole‐based treatment of sternal osteomyelitis aspergillosis in a cardiac recipient.

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