Premium
Successful treatment of Aspergillus fumigatus sternal osteomyelitis with isavuconazole in a heart transplant recipient
Author(s) -
Assaf Ady,
Faure Emmanuel,
Sermet Kevin,
Loridant Severine,
Leroy Jordan,
Goeminne Celine,
Dozier Aurelie,
Chopin MarieCharlotte,
Panaget Sophie,
Faure Karine,
Vuotto Fanny
Publication year - 2020
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.13313
Subject(s) - voriconazole , discontinuation , medicine , aspergillus fumigatus , osteomyelitis , aspergillosis , surgery , sternum , heart transplantation , caspofungin , transplantation , antifungal , dermatology , immunology
A 65‐year‐old man was diagnosed with an invasive Aspergillus fumigatus infection with sternal osteomyelitis 4 months after heart transplantation. Unfortunately, after 8 weeks patient developed severe cutaneous and neurological toxicities induced by voriconazole leading to drug discontinuation. Therefore, isavuconazole was chosen as second‐line therapy. The patient presented a favorable outcome and tolerance was excellent after ten months monotherapy. Here, we report for a first time, an successful isavuconazole‐based treatment of sternal osteomyelitis aspergillosis in a cardiac recipient.