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The nutrition risk index is associated with bacteremia within 30 days after autologous stem cell transplantation in patients with multiple myeloma
Author(s) -
Garzón Herazo Javier Ricardo,
Muñoz Velandia Oscar Mauricio,
Solano Julio Cesar,
Molina Pimienta Luisana,
Figueroa Lemus Wilmer Javier
Publication year - 2020
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.13302
Subject(s) - medicine , bacteremia , multiple myeloma , autologous stem cell transplantation , univariate analysis , transplantation , incidence (geometry) , mucositis , retrospective cohort study , multivariate analysis , surgery , antibiotics , radiation therapy , physics , optics , microbiology and biotechnology , biology
Objectives To assess whether the nutrition risk index (NRI) is associated with the risk of bacteremia within the first days after autologous stem cell transplantation (ASCT) in patients with multiple myeloma (MM). Materials and methods Retrospective cohort study of adult patients with MM taken to ASCT at the Hospital Universitario San Ignacio (Bogotá, Colombia) between 2005 and 2019. The outcome of interest was the incidence of bacteremia at 30 days. Multivariate analysis was used to identify whether the NRI was associated with bacteremia, controlling by different confounding variables. Results One hundred and twenty‐four patients with a median age of 58.5 years (IQR: 54‐64) were included. 47.1% were in stage ISS III. 36.0% had moderate or severe malnourishment (NRI < 97.5). 11.2% presented bacteremia in the first 30 days after transplantation. In the univariate analysis, the NRI < 97.5 was associated with bacteremia (OR: 1.88; 95% CI: 1.30‐2.72, P = .001); however, this association was not significant in the multivariate analysis, unlike the presence of mucositis (OR: 11.59; 95% CI: 1.9‐68.3, <0.01), one or more previous lines of therapy (OR: 12.0; 95% CI: 2.1‐67.4; P < .01), and duration of aplasia (OR: 1.70; 95% CI: 1.2‐2.4, P < .01). Conclusions Patients with moderate or severe malnourishment have a higher incidence of bacteremia in the 30 days post‐ASCT in patients with MM. Additional risk factors associated with bacteremia include the presence of mucositis, one or more previous lines of therapy, and the duration of aplasia.