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Hyperammonemia syndrome due to Ureaplasma infection after liver‐kidney transplant
Author(s) -
Can Chase A.,
Corcorran Maria A.,
Shaw Kathryn W.,
Montenovo Martin,
Sibulesky Lena,
Reyes Jorge D.,
Rayhill Stephen C.,
Larson Anne M.,
Kritek Patricia A.,
Giovanni Shewit,
Castro Iris,
Arora Nayan,
Rakita Robert M.
Publication year - 2020
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.13298
Subject(s) - hyperammonemia , medicine , liver transplantation , ureaplasma , etiology , transplantation , encephalopathy , kidney , gastroenterology , biology , mycoplasma , genetics
Hyperammonemia syndrome, with high levels of ammonia and neurologic dysfunction, is a syndrome with historically high mortality that may occur after solid organ transplantation. Recently, this has been associated with infection due to Ureaplasma , mostly following lung transplantation. We describe the first case of hyperammonemia syndrome due to Ureaplasma infection after liver‐kidney transplantation. Our patient rapidly recovered after specific antibiotic treatment. It is important to consider these infections in the differential diagnosis for encephalopathy post‐transplant, as these organisms often do not grow using routine culture methods and polymerase chain reaction testing is typically required for their detection. This is particularly critical after liver transplantation, where a number of other etiologies may be considered as a cause of hyperammonemia syndrome.