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Utilization of deceased organ donors based on HIV, hepatitis B virus, and hepatitis C virus screening test results
Author(s) -
Theodoropoulos Nicole,
KrollDesrosiers Aimee,
Ison Michael G.
Publication year - 2020
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.13275
Subject(s) - medicine , nucleic acid test , nat , virology , hepatitis b virus , hepatitis c virus , serology , antibody , immunology , organ procurement , hepatitis b , hepatitis c , organ transplantation , virus , transplantation , disease , infectious disease (medical specialty) , computer network , covid-19 , computer science
Background Potential deceased organ donors are screened for human immunodeficiency virus (HIV‐1), hepatitis B virus (HBV), and hepatitis C virus (HCV) with serologic tests and nucleic acid tests (NATs). The results of these tests on the utilization of donors have not been directly measured. Methods Twenty‐six organ procurement organizations (OPOs) provided primary HIV, HBV, and HCV screening results and utilization information for donor referrals evaluated from 2004 to 2017. Additional information regarding donor organ utilization was obtained from the Organ Procurement and Transplantation Network database. Data were analyzed using logistic regression. Results Test results were submitted for 38 166 potential deceased organ donors; 31 (0.1%) were HIV NAT‐negative but seropositive, 5.2% were HBV core antibody‐positive and NAT‐negative, while 1.8% were HCV antibody‐positive and NAT‐negative. Organ utilization of HBV and/or HCV NAT‐negative organs increased over time despite positive antibody status. Conclusions Nucleic acid test detected infections in seronegative donors, especially for HCV. The use of NAT for deceased donor screening correlated with increased utilization of donor organs.