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Bloodstream infection by multidrug‐resistant Streptococcus oralis in a leukemic patient with febrile neutropenia after hematopoietic stem cell transplantation
Author(s) -
Watanabe Noriyuki,
Kobayashi Kiyoko,
Koyama Sachie,
Tabira Mayu,
Matsuno Junpei,
Taji Yoshitada,
Akuzawa Yu,
Ishikawa Maho,
Maeda Tomoya,
Imai Kazuo,
Tarumoto Norihito,
Asou Norio,
Mitsutake Kotaro,
Ebihara Yasuhiro
Publication year - 2020
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.13246
Subject(s) - streptococcus oralis , medicine , streptococcus mitis , bacteremia , neutropenia , hematopoietic stem cell transplantation , febrile neutropenia , meropenem , vancomycin , transplantation , penicillin , daptomycin , multiple drug resistance , blood culture , immunology , microbiology and biotechnology , streptococcus , antibiotics , antibiotic resistance , chemotherapy , biology , bacteria , staphylococcus aureus , genetics
We reported the case of a patient with leukemia who developed febrile neutropenia after hematopoietic stem cell transplantation. Blood culture results revealed the presence of Streptococcus oralis , while antimicrobial susceptibility testing showed the resistance to penicillin and cephem. Furthermore, isolates were not susceptible to either meropenem or daptomycin but not to vancomycin. S oralis is known to belong to Streptococcus mitis group and be a causative agent of bacteremia in the neutropenic patients, but multidrug resistance of S oralis is rare. Our findings suggest that we might pay attention to the emergence of the microorganisms acquiring multidrug resistance in neutropenic patients.