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Disseminated adenovirus infection after autologous stem cell transplant
Author(s) -
Kim Nicole J.,
Hyun Teresa S.,
Pergam Steven A.,
Issaka Rachel B.
Publication year - 2020
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.13238
Subject(s) - medicine , adenovirus infection , cidofovir , viremia , stem cell , transplantation , immunohistochemistry , autologous stem cell transplantation , complication , pathology , immunology , surgery , virus , biology , genetics
Adenovirus is an infrequent but challenging viral complication of transplantation that is rarely reported after autologous stem cell transplant. We present a case of disseminated adenovirus infection in a woman who received an autologous stem cell transplant for treatment of multiple sclerosis. After presenting with post‐transplant episodic diarrhea and viremia, endoscopic biopsies and immunohistochemical staining confirmed the diagnosis of disseminated adenovirus infection. Her symptoms and viremia resolved after treatment with cidofovir. This case demonstrates that a high index of suspicion, a systematic clinical approach, and immunohistochemical tissue staining are necessary to diagnose disseminated adenovirus infection in an unexpected host.