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Neutropenia and renal dysfunction due to intravesical cidofovir for virus‐associated hemorrhagic cystitis after kidney and allogenic hematopoietic stem cell transplantations
Author(s) -
Shimizu Takuya,
Kondo Tadakazu,
Matsumoto Kana,
Hishizawa Masakatsu,
Yamashita Kouhei,
TakaoriKondo Akifumi
Publication year - 2019
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.13185
Subject(s) - hemorrhagic cystitis , cidofovir , medicine , bk virus , neutropenia , nephrotoxicity , hematopoietic stem cell transplantation , stem cell , kidney , transplantation , urology , immunology , virus , kidney transplantation , chemotherapy , biology , genetics
We present a patient with virus‐associated hemorrhagic cystitis who underwent kidney and allogenic hematopoietic stem cell transplantations (allo‐HSCT). Six months post‐allo‐HSCT, adenovirus hemorrhagic cystitis occurred, which has been in remission after a single dose of intravesical cidofovir. This might cause prolonged neutropenia and nephrotoxicity, suggesting cidofovir absorption in the blood.