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Early necrotic skin lesions after a ABO‐incompatible kidney transplantation: The threat of Cunninghamella Spp.
Author(s) -
Belliere Julie,
Rolland Marion,
Tournier Emilie,
Cassaing Sophie,
Iriart Xavier,
Paul Carle,
Kamar Nassim
Publication year - 2019
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.13173
Subject(s) - medicine , transplantation , mucorales , immunosuppression , kidney transplantation , lesion , abo blood group system , pneumonia , surgery , mucormycosis , pathology
A 49‐year‐old man underwent ABO‐incompatible kidney transplantation with a living donor. At day 33 post‐transplantation, he presented with undiagnosed epilepsy with generalized tonic‐clonic seizures. At day 44 post‐transplantation, he developed left‐sided pneumonia attributed to Aspergillus fumigatus and treatment with liposomal amphotericin B was initiated. At day 51 post‐transplantation, necrotic skin lesions appeared. DNA sequencing in a fresh cutaneous biopsy finally identified Cunninghamella Spp., a member of the order Mucorales. Unfortunately, the necrotic lesions spread, and the patient died at day 60 post‐transplantation. This case report highlights the infectious risk related to ABO‐incompatible kidney transplantation and suggests a requirement for rapid identification of every skin lesion, even in the early phases of immunosuppression.