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In sickness and in health: Living HIV positive kidney donation from a wife to her husband, with 7 years' post‐transplant follow‐up
Author(s) -
Grupper Ayelet,
Goykhman Yaacov,
Baruch Roni,
Turner Dan,
Elbirt Daniel,
Okrent Smolar Lily,
Katz Polina,
Nachmany Ido,
Lubezky Nir,
Katchman Eugene
Publication year - 2019
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.13171
Subject(s) - contraindication , medicine , kidney transplantation , context (archaeology) , transplantation , donation , human immunodeficiency virus (hiv) , organ donation , intensive care medicine , immunology , pathology , alternative medicine , law , paleontology , biology , political science
Abstract Human immunodeficiency virus (HIV) infection was traditionally considered an absolute contraindication for kidney transplantation. After the introduction of ART, several studies have demonstrated comparable patient and graft outcomes between HIV‐negative and HIV‐positive kidney recipients. The US Congress passed the HIV Organ Policy Equity (HOPE) Act in 2013, which permits research in the area of HIV‐positive to HIV‐positive transplantation. HIV‐infected living donation is also permitted under the HOPE Act. However, there is a concern regarding the safety of kidney donation in an HIV‐infected person, given the risk of renal disease associated with HIV infection. We report here the case of successful kidney transplantation from HIV‐positive living donor to HIV‐positive recipient performed in our center on July 2012. To the best of our knowledge, this is the earliest case done in this medical context to be reported in the literature, therefore, potentially carrying several important messages to the transplantation community. In the present case, the living‐donor kidney transplant was performed between a married couple infected with same strain of HIV‐1, both on effective ART with efficiently suppressed viral replication and satisfactory pre‐transplantation immune status.