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Delayed spontaneous hepatitis C virus elimination in a renal transplant patient following graft rejection
Author(s) -
Mori Ubaldini Francesca,
Stratta Robert J.,
Nunez Marina
Publication year - 2019
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.13079
Subject(s) - medicine , immunosuppression , clearance , chronic infection , renal transplant , virus , immunology , hepatitis c virus , chronic hepatitis , kidney , immune system , urology
While elimination of the hepatitis C virus (HCV) following acute infection is not uncommon, spontaneous clearance once the infection becomes chronic is extremely rare. The mechanisms involved in the clearance of chronic HCV infection without intervening antiviral therapy are not well known. Herein we describe a case of a renal transplant recipient who acquired HCV infection while immunosuppressed, experienced a rapid histological progression, and thereafter cleared the virus spontaneously long after withdrawal of immunosuppression following kidney graft rejection and failure. We review the literature and summarize the reports of spontaneous clearance of chronic HCV infection in various settings.