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Successful lung transplantation for chronic Mycobacterium abscessus infection in advanced cystic fibrosis, a case series
Author(s) -
Raats Daan,
Lorent Natalie,
Saegeman Veroniek,
Vos Robin,
van Ingen Jakko,
Verleden Geert,
Van Raemdonck Dirk,
Dupont Lieven
Publication year - 2019
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.13046
Subject(s) - medicine , mycobacterium abscessus , cystic fibrosis , lung transplantation , lung infection , transplantation , lung , pulmonary infection , nontuberculous mycobacteria , surgery , mycobacterium , pathology , tuberculosis
Pulmonary Mycobacterium abscessus infection in cystic fibrosis (CF) patients is difficult to treat and considered a contra‐indication for lung transplantation in most centers. We present four CF patients with chronic pulmonary M abscessus infection, in whom lung transplantation was performed. Through intensive treatment before transplantation, we achieved control of the infection in all but one patient. After a mean of 16 months of follow up, 3 patients are doing well, without evidence of local or disseminated recurrence. One patient died early post‐transplant due to an unrelated cause. These findings support the possibility of lung transplantation with favorable outcome in CF patients with M abscessus infection.