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A case of pan‐resistant Burkholderia cepacia complex bacteremic pneumonia, after lung transplantation treated with a targeted combination therapy
Author(s) -
CantónBulnes María Luisa,
Hurtado Martínez Ángela,
LópezCerero Lorena,
Arenzana Seisdedos Ángel,
MerinoBohorquez Vicente,
GarnachoMontero José
Publication year - 2019
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.13034
Subject(s) - medicine , burkholderia cepacia complex , cystic fibrosis , pneumonia , burkholderia , lung transplantation , meropenem , ceftazidime , ceftazidime/avibactam , antibiotics , combination therapy , antibiotic therapy , lung , transplantation , intensive care medicine , pseudomonas aeruginosa , antibiotic resistance , microbiology and biotechnology , bacteria , genetics , biology
We describe a case of one patient with cystic fibrosis who developed a pan‐resistant Burkholderia cepacia complex rapidly progressive bacteraemic pneunonia, following bilateral lung transplantation. The patient was treated with a targeted combination antibiotic therapy (meropenem plus ceftazidime/avibactam plus high doses of nebulized colistimethate sodium). Evolution of the disease was complicated by multiple organ system dysfunction. Finally, clinical improvement and microbiological cure was achieved.