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Donor derived HSV hepatitis in a kidney transplant recipient leading to liver fibrosis and portal hypertension
Author(s) -
Shaw Brian I.,
Nanavati Aditya J.,
Taylor Vanessa,
Miller Rachel A.,
Kappus Matthew,
Barbas Andrew S.
Publication year - 2019
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.13029
Subject(s) - medicine , herpes simplex virus , portal hypertension , liver transplantation , transmission (telecommunications) , kidney transplantation , kidney , hsl and hsv , transplantation , hepatitis c , organ transplantation , fibrosis , immunology , gastroenterology , virology , virus , cirrhosis , electrical engineering , engineering
The unexpected transmission of donor‐derived infection through organ transplantation is a rare event with current donor screening practices. In this case report we describe a probable donor‐derived transmission of Herpes Simplex Virus (HSV)‐2 via deceased donor kidney transplantation resulting in HSV hepatitis in the recipient. This manifested as acute liver failure which resolved with appropriate anti‐viral therapy. Following recovery from the acute liver insult, the patient developed fibrotic liver morphology and portal hypertension, an unusual departure from the typical course.