z-logo
Premium
Reactivation of Chagas disease among heart transplant recipients in the United States, 2012‐2016
Author(s) -
Gray Elizabeth B.,
La Hoz Ricardo M.,
Green Jaime S.,
Vikram Holenarasipur R.,
Benedict Theresa,
Rivera Hilda,
Montgomery Susan P.
Publication year - 2018
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12996
Subject(s) - medicine , chagas disease , immunosuppression , heart transplantation , transplantation , myocarditis , heart failure , disease , heart disease , cardiomyopathy , intensive care medicine , immunology
Background Heart transplantation has been shown to be a safe and effective intervention for progressive cardiomyopathy from chronic Chagas disease. However, in the presence of the immunosuppression required for heart transplantation, the likelihood of Chagas disease reactivation is significant. Reactivation may cause myocarditis resulting in allograft dysfunction and the rapid onset of congestive heart failure. Reactivation rates have been well documented in Latin America; however, there is a paucity of data regarding the risk in non‐endemic countries. Methods We present our experience with 31 patients with chronic Chagas disease who underwent orthotopic heart transplantation in the United States from 2012 to 2016. Patients were monitored following a standard schedule. Results Of the 31 patients, 19 (61%) developed evidence of reactivation. Among the 19 patients, a majority (95%) were identified by laboratory monitoring using polymerase chain reaction testing. One patient was identified after the onset of clinical symptoms of reactivation. All subjects with evidence of reactivation were alive at follow‐up (median: 60 weeks). Conclusions Transplant programs in the United States are encouraged to implement a monitoring program for heart transplant recipients with Chagas disease. Our experience using a preemptive approach of monitoring for Chagas disease reactivation was effective at identifying reactivation before symptoms developed.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here