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Cardiac allograft vasculopathy following fecal microbiota transplantation for recurrent C. difficile infection
Author(s) -
Barfuss Spencer,
Knackstedt Elizabeth Doby,
Jensen Kyle,
Molina Kimberly,
Lal Ashwin
Publication year - 2018
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12983
Subject(s) - medicine , clostridium difficile , fecal bacteriotherapy , heart transplantation , diarrhea , c difficile , transplantation , enterocolitis , feces , antibiotics , gastroenterology , microbiology and biotechnology , biology
We report the case of a 3‐year‐old male who developed recurrent Clostridium difficile infection after receiving an orthotopic heart transplant. Despite multiple courses of antibiotics, C. difficile infection was persistent and he underwent a fecal microbiota transplant. The patient responded with resolution of his diarrhea. However, within 2 months he developed severe mixed rejection with high circulating donor‐specific antibodies and significant coronary vasculopathy. Organ dysfunction led to the need for re‐transplantation. The patient's postoperative course has since been complicated by pneumatosis intestinalis and recurrent C. difficile infection.