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Successful treatment of primary donor‐derived human herpesvirus‐8 infection and hepatic Kaposi Sarcoma in an adult liver transplant recipient
Author(s) -
Fu Whitney,
Merola Jonathan,
Malinis Maricar,
Lacy Jill,
Barbieri Andrea,
Liapakis Annmarie H.,
Mulligan David C.,
Yoo Peter S.
Publication year - 2018
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12966
Subject(s) - medicine , immunosuppression , malignancy , sarcoma , human herpesvirus , kaposi's sarcoma , immunology , pathology
Kaposi sarcoma ( KS ) may rarely occur in transplant recipients through primary human herpesvirus‐8 ( HHV ‐8) infection from a seropositive donor. This report describes a patient who developed hepatic KS after receiving a split liver transplant from an HHV ‐8‐positive donor. The recipient was treated with liposomal doxorubicin after reduction in immunosuppression led to acute cellular rejection. This treatment achieved regression of KS while preserving allograft function, demonstrating a successful therapeutic strategy for this malignancy.