Safe administration of rotavirus vaccine in a cohort of infants exposed to immunosuppressive drugs during gestation | Zendy

Dinelli Maria Isabel S. | Zendy; dos Santos Amélia M. N. | Zendy; Weckx Lily Y. | Zendy; MoraesPinto Maria Isabel | Zendy

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Safe administration of rotavirus vaccine in a cohort of infants exposed to immunosuppressive drugs during gestation

Author(s) -

Dinelli Maria Isabel S.,

dos Santos Amélia M. N.,

Weckx Lily Y.,

MoraesPinto Maria Isabel

Publication year - 2018

Publication title -

transplant infectious disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.69

H-Index - 67

eISSN - 1399-3062

pISSN - 1398-2273

DOI - 10.1111/tid.12951

Subject(s) - medicine , contraindication , azathioprine , rotavirus vaccine , gestation , adverse effect , rotavirus , pregnancy , tacrolimus , regimen , prednisone , pediatrics , diarrhea , transplantation , alternative medicine , disease , pathology , biology , genetics

In utero exposure to immunosuppressive drugs might be a contraindication to rotavirus vaccine, but that may vary according to the immunosuppressive regimen. We evaluated 24 infants born to kidney transplanted mothers exposed to 3 immunosuppressants during pregnancy (prednisone, azathioprine, and tacrolimus or cyclosporine) and 31 control infants not exposed to these medications. No differences in adverse events were detected after rotavirus vaccination at 2 and 4 months.

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