Premium
Safe administration of rotavirus vaccine in a cohort of infants exposed to immunosuppressive drugs during gestation
Author(s) -
Dinelli Maria Isabel S.,
dos Santos Amélia M. N.,
Weckx Lily Y.,
MoraesPinto Maria Isabel
Publication year - 2018
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12951
Subject(s) - medicine , contraindication , azathioprine , rotavirus vaccine , gestation , adverse effect , rotavirus , pregnancy , tacrolimus , regimen , prednisone , pediatrics , diarrhea , transplantation , alternative medicine , disease , pathology , biology , genetics
In utero exposure to immunosuppressive drugs might be a contraindication to rotavirus vaccine, but that may vary according to the immunosuppressive regimen. We evaluated 24 infants born to kidney transplanted mothers exposed to 3 immunosuppressants during pregnancy (prednisone, azathioprine, and tacrolimus or cyclosporine) and 31 control infants not exposed to these medications. No differences in adverse events were detected after rotavirus vaccination at 2 and 4 months.