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Donor‐derived multiorgan transmission of mixed P. malariae and P. ovale infection: Impact of globalization on post‐transplant infections
Author(s) -
MartínDávila Pilar,
Norman Francesca,
FortúnAbete Jesus,
Píris Miguel,
Lovatti Ruben,
Rubio Jose Miguel,
MartinezPérez Adolfo,
Graus Javier,
Ta Gema,
Villarubia Jesus,
Mahillo Beatriz,
LópezVélez Rogelio
Publication year - 2018
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12938
Subject(s) - medicine , malaria , primaquine , plasmodium ovale , gastroenterology , asymptomatic , plasmodium malariae , transmission (telecommunications) , immunology , liver transplantation , transplantation , chloroquine , surgery , plasmodium vivax , plasmodium falciparum , engineering , electrical engineering
A 57‐year‐old man was admitted with fever and thrombocytopenia 1 month after renal transplantation. He had never received a blood transfusion or travelled outside Spain. A peripheral blood smear revealed Plasmodium malariae and P. ovale parasites, diagnosis confirmed later by malaria PCR . The donor, from Equatorial Guinea, had negative thick and thin blood smears and rapid malaria antigen test prior to organ donation. Peripheral blood malaria PCR was not performed during donor screening. The second renal recipient and the liver recipient were evaluated and were found to be asymptomatic. Thick and thin films and rapid malaria diagnostic tests were negative for both patients and blood for malaria PCR was sent to the referral laboratory. The index patient was treated with oral chloroquine diphosphate, with a favorable outcome and was considered cured. Malaria PCR was negative for the other renal recipient and positive for P. malariae and P. ovale curtisi for the liver transplant patient. Both were treated with oral chloroquine and the liver recipient also completed treatment with primaquine phosphate. This reported case of multiorgan transmission of mixed malaria infection highlights the importance of PCR ‐based tests for Plasmodium in the screening of donors from endemic areas.