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De novo CMV ‐associated collapsing focal segmental glomerulosclerosis in a kidney transplant recipient
Author(s) -
Patel Anup M.,
Zenenberg Robert D.,
Goldberg Ryan J.
Publication year - 2018
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12884
Subject(s) - medicine , focal segmental glomerulosclerosis , kidney transplantation , ganciclovir , cytomegalovirus , nephrotic syndrome , transplantation , kidney , immunology , pathology , gastroenterology , glomerulonephritis , herpesviridae , viral disease , human cytomegalovirus , virus
Collapsing focal segmental glomerulosclerosis ( FSGS ) is a variant of FSGS and is associated with severe nephrotic syndrome and acute kidney injury and can occur after kidney transplantation. The exact mechanism of collapsing FSGS after kidney transplantation is unknown, but potential causes include autoimmune diseases, certain malignancies, bisphosphonates, m‐ TOR inhibitors, interferon‐alpha, HIV infection, and other viruses. We describe a case of de novo Cytomegalovirus ( CMV )‐associated collapsing FSGS in a kidney transplant recipient with a UL 97 phosphotransferase mutation that was successfully treated with intravenous ganciclovir, intravenous immunoglobulin, and steroids.