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Recurrent bacterial pneumonia due to immunoglobulin G2 subclass deficiency after allogeneic hematopoietic stem cell transplantation: Efficacy of immunoglobulin replacement
Author(s) -
Yamazaki Rie,
Kikuchi Taku,
Kato Jun,
Sakurai Masatoshi,
Koda Yuya,
Hashida Risa,
Yamane Yusuke,
Abe Ryohei,
Hasegawa Naoki,
Okamoto Shinichiro,
Mori Takehiko
Publication year - 2018
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12863
Subject(s) - medicine , hematopoietic stem cell transplantation , subclass , pneumonia , immunology , streptococcus pneumoniae , antibody , transplantation , microbiology and biotechnology , biology , antibiotics
Immunoglobulin (Ig) G2 subclass deficiency is known to be associated with recurrent bacterial respiratory infections caused by capsulated bacteria. We encountered a case of recurrent pneumonia due to Streptococcus pneumoniae after allogeneic hematopoietic stem cell transplantation ( HSCT ). IgG2 subclass level was specifically low, and prophylactic Ig replacement successfully prevented subsequent infections. However, the cessation of Ig replacement resulted in subsequent pneumonia. These findings suggested that IgG2 deficiency could be a cause of recurrent pneumococcal infection after allogeneic HSCT .