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Breakthrough E xophiala dermatitidis infection during prophylactic administration of micafungin during second umbilical cord blood transplantation after graft failure
Author(s) -
Watanabe Naoki,
Gotoh Akihiko,
Shirane Shuichi,
Hamano Yasuharu,
Hirai Yuji,
Shimizu Maika,
Nakamura Ayako,
Matsumoto Kana,
Morita Kunihiko,
Mori Takeshi,
Ohsaka Akimichi,
Komatsu Norio
Publication year - 2018
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12833
Subject(s) - micafungin , medicine , umbilical cord , umbilical cord blood transplantation , transplantation , blood stream , surgery , hematopoietic stem cell transplantation , antifungal , voriconazole , immunology , dermatology
E xophiala dermatitidis infections in patients with hematological malignancies are very rare. Our patient had a blood stream infection caused by E . dermatitidis following the second umbilical cord blood transplantation ( UCBT ) after graft failure during the first UCBT . To our knowledge, this is the first report describing a breakthrough fungal infection caused by E . dermatitidis during the prophylactic administration of micafungin ( MCFG ). Therefore, MCFG ‐treated patients should be monitored for breakthrough E . dermatitidis infection during hematopoietic stem cell transplantation.