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Sinusitis caused by E xserohilum rostratum after cord blood transplantation for myelodysplastic syndrome: A case report and literature review
Author(s) -
Kohashi Sumiko,
Toyama Takaaki,
Hashimoto Norisato,
Sakurai Masatoshi,
Kato Jun,
Kikuchi Taku,
Koda Yuya,
Sugita Kayoko,
Hasegawa Naoki,
Yarita Kyoko,
Kamei Katsuhiko,
Okamoto Shinichiro,
Mori Takehiko
Publication year - 2018
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12805
Subject(s) - medicine , sinusitis , neutropenia , hematopoietic stem cell transplantation , transplantation , surgery , chemotherapy
Invasive fungal disease is a serious infectious complication of allogeneic hematopoietic stem cell transplantation ( HSCT ). E xserohilum rostratum is a species causing phaeohyphomycosis, which rarely causes invasive disease in humans. We treated a case of sinusitis caused by E . rostratum after cord blood transplantation ( CBT ). A 60‐year‐old man with myelodysplastic syndrome, who had a medical history of an operation to correct deviation of the nasal septum, developed sinusitis caused by E . rostratum under prolonged profound neutropenia after a second CBT because of the graft rejection of the first transplantation. Liposomal amphotericin B improved the sinusitis. A literature review revealed nine reported cases of sinusitis caused by E . rostratum , including our case. Although five cases had severe neutropenia at onset ( HSCT recipients, n = 2; aplastic anemia, n = 3), the remaining four had no preexisting immunosuppressive conditions. However, three of the four patients had preexisting nasal diseases with or without a history of surgery, as in our case. Excluding our case, the outcome was fatal in five neutropenic patients, whereas the four patients without neutropenia recovered. Although sinusitis caused by E . rostratum is rare, E . rostratum should be recognized as a possible pathogen causing sinusitis in highly immunosuppressed patients such as HSCT recipients. Preexisting nasal disease and/or nasal surgery could be risks for this infection.